The role of aldosterone inhibitors in cardiac ischemia–reperfusion injury

Myocardial ischaemia–reperfusion (I/R) injury is a well-known term for exacerbation of cellular destruction and dysfunction after the restoration blood flow to previously ischaemic heart. A vast number studies that have demonstrated role mineralocorticoids in cardiovascular diseases based on use pharmacological mineralocorticoid receptor (MR) antagonists. This review paper aimed summarize current knowledge effects MR antagonists myocardial I/R as well postinfarction remodeling. Animal models, predominantly Langendorff technique left anterior descending coronary artery occlusion, confirmed potency preconditioning postconditioning agents limiting infarct size Several preclinical rodents established proved possible mechanisms cardioprotection by antagonists, such reduction oxidative stress, inflammation, apoptosis, therefore zone. However, results some clinical trials are inconsistent, since they reported no benefit acute infarction. Due this, further ongoing regarding antagonist administration patients with infarction being awaited great interest.